NMDA receptor subunits: Function and pharmacology
نویسندگان
چکیده
منابع مشابه
NMDA receptor subunits: function and pharmacology.
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key roles in excitatory synaptic transmission. Because of their involvement in numerous neurological disorders, NMDARs are also targets of therapeutic interest. NMDARs occur as multiple subtypes which differ in their subunit composition and in their biophysical and p...
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LYl7l555. SinLe forskolin activates adenylyl cyclase, effects of Dr receptors on Na'/X+-ATPase would then be mediated via protein phosphorylation and CAMP-dependent protein kinase. There are reports that Na+/K+-ATPase may be regulated by phosphoryl-ation, and CAMP has been reported to inhibit the enzyme via a cAMP-&pendent protein kinase7, consistent with the scheme outlined above. However, it ...
متن کاملStructure, function, and pharmacology of NMDA receptor channels.
NMDA receptors have received much attention over the last few decades, due to their role in many types of neural plasticity on the one hand, and their involvement in excitotoxicity on the other hand. There is great interest in developing clinically relevant NMDA receptor antagonists that would block excitotoxic NMDA receptor activation, without interfering with NMDA receptor function needed for...
متن کامل[Structure and function of NMDA-type glutamate receptor subunits].
INTRODUCTION To review the physiology of the glutamate receptor subunits such as N-methyl-D-aspartate (NMDA). DEVELOPMENT Glutamic acid (Glu) is the major excitatory neurotransmitter in the central nervous system which interacts with two types classified into two types: metabotropic and ionotropic. Ionotropic receptors are classified according to the affinity of their specific agonists: N-met...
متن کاملNMDA receptor subunits: diversity, development and disease.
N-methyl-D-aspartate receptors (NMDARs) are present at many excitatory glutamate synapses in the central nervous system and display unique properties that depend on their subunit composition. Biophysical, pharmacological and molecular methods have been used to determine the key features conferred by the various NMDAR subunits, and have helped to establish which NMDAR subtypes are present at par...
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ژورنال
عنوان ژورنال: Acute Pain
سال: 2007
ISSN: 1366-0071
DOI: 10.1016/j.acpain.2007.04.009